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sheep anti trem2  (R&D Systems)


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    R&D Systems sheep anti trem2
    Sheep Anti Trem2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 141 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sheep+anti+trem2/Mouse+TREM2+Antibody/bio_rxiv__64898__2026__02__23__707565-50-13-15
    Average 96 stars, based on 141 article reviews
    sheep anti trem2 - by Bioz Stars, 2026-09
    96/100 stars

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    Related Articles

    Blocking Assay:

    Article Title: PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology.
    Article Snippet: .. After blocking, the sections were incubated overnight at 4◦C in 5% normal donkey serum in PBST with the following primary antibodies: rabbit anti-Iba1 (1:1000,Wako, #019-19741), sheep anti-TREM2 (1:500, R&D Systems, #AF1729), goat anti-Iba1 (1:1000; Novus Biologicals, NB100-1028), rat antiLAMP1 (1:1000; Abcam, Ab25245), rabbit anti-CD68 (1:1000; Abcam, Ab283654); mouse anti-MOAB2 (1:1000; Novus Biologicals, NBP213075). .. After incubating overnight, the sections were washed three times in PBST and incubated for 1 hour at RT with the appropriate species-specific secondary antibodies conjugated with AlexaFluor in 5% normal donkey serum in PBST (1:1000, Invitrogen).

    Article Title: PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology.
    Article Snippet: .. After blocking, the membranes were incubated overnight at 4◦C in 5% BSA in TBST with the following primary antibodies: rabbit anti-PLCG2 (1:500; Cell Signaling, #3872), sheep anti-TREM2 (1:500, R&D Systems, #AF1729), mouse anti-β-actin (1:5000; Santa Cruz Biotechnology, sc-47778), rabbit anti-CD11c (1:1000; Cell Signaling, 97585S), mouse anti-IL4R alpha (1:250; R&D Systems, MAB530), mouse anti-GAPDH (1:5000; Santa Cruz Biotechnology, sc-32233). ..

    Incubation:

    Article Title: PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology.
    Article Snippet: .. After blocking, the sections were incubated overnight at 4◦C in 5% normal donkey serum in PBST with the following primary antibodies: rabbit anti-Iba1 (1:1000,Wako, #019-19741), sheep anti-TREM2 (1:500, R&D Systems, #AF1729), goat anti-Iba1 (1:1000; Novus Biologicals, NB100-1028), rat antiLAMP1 (1:1000; Abcam, Ab25245), rabbit anti-CD68 (1:1000; Abcam, Ab283654); mouse anti-MOAB2 (1:1000; Novus Biologicals, NBP213075). .. After incubating overnight, the sections were washed three times in PBST and incubated for 1 hour at RT with the appropriate species-specific secondary antibodies conjugated with AlexaFluor in 5% normal donkey serum in PBST (1:1000, Invitrogen).

    Article Title: PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology.
    Article Snippet: .. After blocking, the membranes were incubated overnight at 4◦C in 5% BSA in TBST with the following primary antibodies: rabbit anti-PLCG2 (1:500; Cell Signaling, #3872), sheep anti-TREM2 (1:500, R&D Systems, #AF1729), mouse anti-β-actin (1:5000; Santa Cruz Biotechnology, sc-47778), rabbit anti-CD11c (1:1000; Cell Signaling, 97585S), mouse anti-IL4R alpha (1:250; R&D Systems, MAB530), mouse anti-GAPDH (1:5000; Santa Cruz Biotechnology, sc-32233). ..

    Immunostaining:

    Article Title: Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling.
    Article Snippet: Article Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling

    Labeling:

    Article Title: Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling.
    Article Snippet: Article Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling



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    sheep anti-trem2  (R&D Systems Hematology)
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    a. Flow chart of injection of SB290157. The injection of SB290157 started from the 4 weeks after tamoxifen induction, the frequency of injections is 3 times per week. b. Scores of nest building. The results showed that the injection of SB290157 did not alleviate the abilities of nest building of the AE-cKO mice. N = 5 per group. c. Rotarod test. The results showed that the injection of SB290157 did not alleviate the run time on the rotarod of the AE-cKO mice. N = 5 per group. d. Y-maze test. The results showed that the injection of SB290157 did not alleviate the behavior abnormality of the AE-cKO mice. N = 5 per group. e-g. Representative images of Iba1 (red) immunostaining ( e ) and quantification ( f,g ) in the cortices of mice. The results showed that the injection of SB290157 significantly decreased the activation of microglia in the cortices of the AE-cKO mice, but did not affect the count of Iba. h, i. Representative images of Iba1 (red) and CD68 (green) immunostaining ( h ) and quantification ( i ) in the cortices of mice. The results showed that the injection of SB290157 significantly decreased the elevation of co-labeled cells stained by Iba1 and CD68 antibodies in the AE-cKO mice. j, k. Representative images of Iba1 (red) and TSPO (green) immunostaining ( j ) and quantification ( k ) in the cortices of mice. The results showed that the injection of SB290157 significantly downregulated the enhancement of co-labeled cells stained by Iba1 and TSPO antibodies in the AE-cKO mice. l, m. Representative images of Iba1 (red) and <t>Trem2</t> (green) immunostaining ( l ) and quantification ( m ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly decreased the elevation of co-labeled cells stained by Iba1 and Trem2 antibodies in the AE-cKO mice. N = 5 mice per group. n-p. Representative images of western blotting ( n ) and quantification ( o, p ) of synaptophysin and PSD95 in the cortices of mice. The results showed that the injection of SB290157 significantly alleviated the reduction of synaptophysin ( n, p ) and PSD95 ( n, o ) in the cortices of the AE-cKO mice. N = 6 mice per group. The data represent mean ± SEM. * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001, one-way ANOVA followed by Tukey’s post hoc test. Scale bars, 25 μm.
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    Image Search Results


    a. Flow chart of injection of SB290157. The injection of SB290157 started from the 4 weeks after tamoxifen induction, the frequency of injections is 3 times per week. b. Scores of nest building. The results showed that the injection of SB290157 did not alleviate the abilities of nest building of the AE-cKO mice. N = 5 per group. c. Rotarod test. The results showed that the injection of SB290157 did not alleviate the run time on the rotarod of the AE-cKO mice. N = 5 per group. d. Y-maze test. The results showed that the injection of SB290157 did not alleviate the behavior abnormality of the AE-cKO mice. N = 5 per group. e-g. Representative images of Iba1 (red) immunostaining ( e ) and quantification ( f,g ) in the cortices of mice. The results showed that the injection of SB290157 significantly decreased the activation of microglia in the cortices of the AE-cKO mice, but did not affect the count of Iba. h, i. Representative images of Iba1 (red) and CD68 (green) immunostaining ( h ) and quantification ( i ) in the cortices of mice. The results showed that the injection of SB290157 significantly decreased the elevation of co-labeled cells stained by Iba1 and CD68 antibodies in the AE-cKO mice. j, k. Representative images of Iba1 (red) and TSPO (green) immunostaining ( j ) and quantification ( k ) in the cortices of mice. The results showed that the injection of SB290157 significantly downregulated the enhancement of co-labeled cells stained by Iba1 and TSPO antibodies in the AE-cKO mice. l, m. Representative images of Iba1 (red) and Trem2 (green) immunostaining ( l ) and quantification ( m ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly decreased the elevation of co-labeled cells stained by Iba1 and Trem2 antibodies in the AE-cKO mice. N = 5 mice per group. n-p. Representative images of western blotting ( n ) and quantification ( o, p ) of synaptophysin and PSD95 in the cortices of mice. The results showed that the injection of SB290157 significantly alleviated the reduction of synaptophysin ( n, p ) and PSD95 ( n, o ) in the cortices of the AE-cKO mice. N = 6 mice per group. The data represent mean ± SEM. * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001, one-way ANOVA followed by Tukey’s post hoc test. Scale bars, 25 μm.

    Journal: bioRxiv

    Article Title: Apolipoprotein E ε4 exacerbates microglia-mediated complement-dependent synapse loss caused by neuronal Tpk deficiency

    doi: 10.1101/2025.01.16.633468

    Figure Lengend Snippet: a. Flow chart of injection of SB290157. The injection of SB290157 started from the 4 weeks after tamoxifen induction, the frequency of injections is 3 times per week. b. Scores of nest building. The results showed that the injection of SB290157 did not alleviate the abilities of nest building of the AE-cKO mice. N = 5 per group. c. Rotarod test. The results showed that the injection of SB290157 did not alleviate the run time on the rotarod of the AE-cKO mice. N = 5 per group. d. Y-maze test. The results showed that the injection of SB290157 did not alleviate the behavior abnormality of the AE-cKO mice. N = 5 per group. e-g. Representative images of Iba1 (red) immunostaining ( e ) and quantification ( f,g ) in the cortices of mice. The results showed that the injection of SB290157 significantly decreased the activation of microglia in the cortices of the AE-cKO mice, but did not affect the count of Iba. h, i. Representative images of Iba1 (red) and CD68 (green) immunostaining ( h ) and quantification ( i ) in the cortices of mice. The results showed that the injection of SB290157 significantly decreased the elevation of co-labeled cells stained by Iba1 and CD68 antibodies in the AE-cKO mice. j, k. Representative images of Iba1 (red) and TSPO (green) immunostaining ( j ) and quantification ( k ) in the cortices of mice. The results showed that the injection of SB290157 significantly downregulated the enhancement of co-labeled cells stained by Iba1 and TSPO antibodies in the AE-cKO mice. l, m. Representative images of Iba1 (red) and Trem2 (green) immunostaining ( l ) and quantification ( m ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly decreased the elevation of co-labeled cells stained by Iba1 and Trem2 antibodies in the AE-cKO mice. N = 5 mice per group. n-p. Representative images of western blotting ( n ) and quantification ( o, p ) of synaptophysin and PSD95 in the cortices of mice. The results showed that the injection of SB290157 significantly alleviated the reduction of synaptophysin ( n, p ) and PSD95 ( n, o ) in the cortices of the AE-cKO mice. N = 6 mice per group. The data represent mean ± SEM. * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001, one-way ANOVA followed by Tukey’s post hoc test. Scale bars, 25 μm.

    Article Snippet: The following primary antibodies were used: rat anti-Iba1 (1:500, ab283346, Abcam), goat anti-Iba1 (1:200, ab5076, Abcam), goat anti-GFAP (1:200, ab53554, Abcam), mouse anti-NeuN (1:200, MAB377, Millipore), rabbit anti-CD68 (1:200, ab283654, Abcam), sheep anti-trem2 (1:200, AF1729, R&D), rabbit anti-4G8 (1:200,800702, Bio Legend), rabbit anti-TSPO (1:2000, ab109497, Abcam), rat anti-C3 (1:200, ab11862, Abcam), and rabbit anti-C1q (1:200, ab182451,abcam).

    Techniques: Injection, Immunostaining, Activation Assay, Labeling, Staining, Knock-In, Western Blot

    a, b. Representative images of Iba1 (green) immunostaining ( a ) and quantification ( b ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly worsened the activation of microglia in the cortices induced by neuronal Tpk ablation, but did not affect those in the mice without Tpk knockout. c, d. Representative images of Iba1 (red) and TSPO (green) immunostaining ( c ) and quantification ( d ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly upregulated the enhancement of co-labeled cells by Iba1 and TSPO antibodies in the cKO mice, but did not affect those in mice without Tpk knockout. e, f. Representative images of Iba1 (red) and CD68 (green) immunostaining ( e ) and quantification ( f ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly exacerbated the elevation of co-labeled cells by Iba1 and CD68 antibodies in the cKO mice, but did affect those in mice without Tpk knockout. g, h. Representative images of Iba1 (green) and Trem2 (red) immunostaining ( g ) and quantification ( h ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly aggravated the enhancement of co-labeled cells by Iba1 and Trem2 antibodies in the cKO mice but did not affect those in mice without Tpk knockout. N = 5 mice per group. The data represent mean ± SEM. * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001, one-way ANOVA followed by Tukey’s post hoc test. Scale bars, 25 μm. i Representative images of immunostaining of Iba1 (red) and PSD95 (green) i n the cortices of mice. The results showed that microglia-mediated synaptic phagocytosis presented by PSD95 in the microglia. Scale bars, 10 μ

    Journal: bioRxiv

    Article Title: Apolipoprotein E ε4 exacerbates microglia-mediated complement-dependent synapse loss caused by neuronal Tpk deficiency

    doi: 10.1101/2025.01.16.633468

    Figure Lengend Snippet: a, b. Representative images of Iba1 (green) immunostaining ( a ) and quantification ( b ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly worsened the activation of microglia in the cortices induced by neuronal Tpk ablation, but did not affect those in the mice without Tpk knockout. c, d. Representative images of Iba1 (red) and TSPO (green) immunostaining ( c ) and quantification ( d ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly upregulated the enhancement of co-labeled cells by Iba1 and TSPO antibodies in the cKO mice, but did not affect those in mice without Tpk knockout. e, f. Representative images of Iba1 (red) and CD68 (green) immunostaining ( e ) and quantification ( f ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly exacerbated the elevation of co-labeled cells by Iba1 and CD68 antibodies in the cKO mice, but did affect those in mice without Tpk knockout. g, h. Representative images of Iba1 (green) and Trem2 (red) immunostaining ( g ) and quantification ( h ) in the cortices of mice. The results showed that the humanized APOE4 knock-in significantly aggravated the enhancement of co-labeled cells by Iba1 and Trem2 antibodies in the cKO mice but did not affect those in mice without Tpk knockout. N = 5 mice per group. The data represent mean ± SEM. * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001, one-way ANOVA followed by Tukey’s post hoc test. Scale bars, 25 μm. i Representative images of immunostaining of Iba1 (red) and PSD95 (green) i n the cortices of mice. The results showed that microglia-mediated synaptic phagocytosis presented by PSD95 in the microglia. Scale bars, 10 μ

    Article Snippet: The following primary antibodies were used: rat anti-Iba1 (1:500, ab283346, Abcam), goat anti-Iba1 (1:200, ab5076, Abcam), goat anti-GFAP (1:200, ab53554, Abcam), mouse anti-NeuN (1:200, MAB377, Millipore), rabbit anti-CD68 (1:200, ab283654, Abcam), sheep anti-trem2 (1:200, AF1729, R&D), rabbit anti-4G8 (1:200,800702, Bio Legend), rabbit anti-TSPO (1:2000, ab109497, Abcam), rat anti-C3 (1:200, ab11862, Abcam), and rabbit anti-C1q (1:200, ab182451,abcam).

    Techniques: Immunostaining, Knock-In, Activation Assay, Knock-Out, Labeling